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Ritonavir or lopinavir/ritonavir tremendously raise plasma concentrations of oxycodone in healthy human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin significantly lowers plasma concentrations of oxycodone on account of powerful induction of CYP3A4.Opioids like oxycodone hydrochloride could affect the hypothalam